Human MTHFD2 in complex with compound 21 and 15

(2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl)carbamoylamino]phenyl]carbonylamino]pentanedioic acid
(4-(3-(4-amino-6-hydroxypyrimidin-5-yl)ureido)benzoyl)-L-glutamic acid

(2S)-2-[[4-[[1-[(3,4-dichlorophenyl)methyl]-3,7-dimethyl-2,6-bis(oxidanylidene)purin-8-yl]amino]phenyl]carbonylamino]pentanedioic acid
(4-((1-(3,4-dichlorobenzyl)-3,7-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)amino)benzoyl)-L-glutamic acid

Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2).

LN2-cooled, Fixed-Exit Double Crystal Monochromator

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

isopropanol, bis-Tris pH 7.1, PEG 200, PEG 3350, glycerol

MTHFD2, methylenetetrahydrofolate dehydrogenase 2, 1C metabolism, mitocondria, OXIDOREDUCTASE