RabGGTase in complex with covalently bound Psoromic acid

4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-6-carboxylic acid

Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase

UNP residues 1-237 and 353-441 from Geranylgeranyl transferase type-2 subunit alpha (Q08602, PGTA_RAT) connected by a linker Ala-Gly-Ser-Gly.
Geranylgeranyl transferase type-2 subunit alpha

Geranylgeranyl transferase type-2 subunit beta

Geranylgeranyl transferase type II subunit alpha, Rab geranyl-geranyltransferase subunit alpha, Rab GG transferase alpha, Rab GGTase alpha, Rab geranylgeranyltransferase subunit alpha

Geranylgeranyl transferase type II subunit beta, GGTase-II-beta, Rab geranyl-geranyltransferase subunit beta, Rab GG transferase beta, Rab GGTase beta, Rab geranylgeranyltransferase subunit beta, Type II protein geranyl-geranyltransferase subunit beta

20mM Hepes pH7.2, 100mM NaCl, 2mM DTT, 15% PEG 3350, 0.2M Ca Acetate, 0.1M Hepes pH7.2, VAPOR DIFFUSION, HANGING DROP, temperature 285K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Geranylgeranyl transferase type-2 subunit alpha (E.C.2.5.1.60), Geranylgeranyl transferase type-2 subunit beta (E.C.2.5.1.60)

prenylation, inhibition, Psoromic acid, TRANSFERASE-TRANSFERASE INHIBITOR complex