Cryo-EM structure of SARS-CoV-2 Spike D614G variant, one RBD-up conformation 2

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation.

D614G variant, one RBD-up conformation 2

Severe acute respiratory syndrome coronavirus 2

blot for 2.5 seconds before plunging; blot force: 0; waiting time: 30s

Ministry of Science and Technology (MoST, Taiwan)

Cryo-EM structure of SARS-CoV-2 Spike D614G varian, one RBD-up conformation 2

The residues 682-685 (GSAS) and residues 986-987 (PP) are designed for protein stabilization.

scanning transmission electron microscopy
SARS-CoV-2, Spike protein, VIRAL PROTEIN