Human phosphodiesterase 9 in complex with inhibitors

Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (E.C.3.1.4.35)