Crystal Structure of Burkholderia cenocepacia HldA in Complex with an ATP-competitive Inhibitor

{[2-({[5-(2,6-dimethoxyphenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetic acid

Structural-functional studies of Burkholderia cenocepacia D-glycero-beta-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties.

0.1M HEPES, 20% PEG 10000, 8% ethylene glycol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.0K

Crystal Structure of Burkholderia cenocepacia HldA

LPS-heptose Biosynthesis, Beta-clasp Dimerization Region, PfkB Carbohydrate Kinase, Phosphorylation, Transferase-Transferase Inhibitor complex