Crystal structure of TadAC-1.17 in a complex with ssDNA

Improved cytosine base editors generated from TadA variants.

DNA (5'-D(P*GP*CP*GP*GP*CP*TP*(D8A)P*CP*GP*GP*A)-3')

deaminase, ssDNA, TadAC, DNA BINDING PROTEIN, DNA BINDING PROTEIN-DNA complex

(chain A and (resid 6 through 12 or resid 14 through 60 or resid 62 through 63 or resid 65 through 97 or (resid 98 and (name N or name CA or name C or name O or name CB or name CG or name CD )) or resid 99 through 100 or resid 102 through 106 or (resid 107 and (name N or name CA or name C or name O or name CB or name CG or name CD )) or resid 108 through 126 or (resid 127 and (name N or name CA or name C or name O or name CB )) or resid 128 through 152 or (resid 154 through 155 and (name N or name CA or name C or name O or name CB ))))

(chain B and (resid 6 through 12 or resid 14 through 20 or (resid 21 through 22 and (name N or name CA or name C or name O or name CB )) or resid 23 through 38 or (resid 39 and (name N or name CA or name C or name O or name CB )) or resid 40 through 60 or resid 62 through 63 or resid 65 through 97 or (resid 98 and (name N or name CA or name C or name O or name CB or name CG or name CD )) or resid 99 through 100 or resid 102 through 106 or (resid 107 and (name N or name CA or name C or name O or name CB or name CG or name CD )) or resid 108 through 126 or (resid 127 and (name N or name CA or name C or name O or name CB )) or resid 128 through 152 or (resid 154 through 155 and (name N or name CA or name C or name O or name CB ))))

(chain C and (resid 6 through 12 or resid 14 through 20 or (resid 21 through 22 and (name N or name CA or name C or name O or name CB )) or resid 23 through 38 or (resid 39 and (name N or name CA or name C or name O or name CB )) or resid 40 through 60 or resid 62 through 63 or resid 65 through 97 or (resid 98 and (name N or name CA or name C or name O or name CB or name CG or name CD )) or resid 99 through 100 or resid 102 through 126 or (resid 127 and (name N or name CA or name C or name O or name CB )) or resid 128 through 152 or (resid 154 through 155 and (name N or name CA or name C or name O or name CB ))))

(chain D and (resid 6 through 12 or resid 14 through 20 or (resid 21 through 22 and (name N or name CA or name C or name O or name CB )) or resid 23 through 60 or resid 62 through 63 or resid 65 through 100 or resid 102 through 152 or resid 154 through 155))