Crystal Structure of Human Indoleamine 2,3-dioxygenagse 1 (hIDO1) Complexed with 6-Bromo-1H-indazol-4-amine (1)

X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.

IDO-1,Indoleamine-pyrrole 2,3-dioxygenase

15% to 23% PEG 8000, 0.2M ammonium acetate

National Natural Science Foundation of China (NSFC)

Indoleamine 2,3-dioxygenase 1 (E.C.1.13.11.52)

Indoleamine 2, 3-dioxygenase 1, OXIDOREDUCTASE