The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12.

NAG A 313 HAS WRONG CHIRALITY AT ATOM C1

Si(111), Side scattering bent cube-root I-beam single crystal; asymmetric cut 4.965 degs

IL-12B, IL-12 subunit p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, NK cell stimulatory factor chain 2, NKSF2

IL-23 subunit alpha, Interleukin-23 subunit p19, IL-23p19

Gp67 signal sequence at N-terminus and 6xHis tag at C-terminus

20% PEG3350, 0.2M potassium nitrate, 0.1M Hepes-NaOH pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Interleukin-12 subunit beta precursor, Interleukin-23 subunit alpha precursor

four-helix bundle cytokine, Ig domain, Cytokine, Glycoprotein, Immunoglobulin domain, Secreted, Antiviral defense, Immune response, Inflammatory response, Innate immunity, Tissue remodeling, IMMUNE SYSTEM, IMMUNE SYSTEM-CYTOKINE COMPLEX