Structure of Human PARP-1 bound to a DNA double strand break

Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1.

PARP-1, NAD(+) ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1

7% Peg 3350, 10% ethylene glycol, 100 mM Hepes, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K

AUTHORS STATE THAT V762A IS A NATURAL VARIANT.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

PARP, poly(ADP-ribose) polymerase, DNA binding protein, adp-ribosyl transferase, PARP-like zinc finger, poly(adp-ribosyl)ation, DNA damage detection, TRANSFERASE-DNA complex