Crystal Structure of PG16 Fab in Complex with V1V2 Region from HIV-1 strain ZM109

beta-D-galactose; D-galactose; galactose

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

N-acetylneuraminic acid; sialic acid; alpha-sialic acid; O-SIALIC ACID

Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16.

N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose

20% Isopropanol, 15% PEG 3550, 0.2M ammonium citrate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K

PG16 Fab Heavy Chain, PG16 Fab Light Chain, 1FD6-V1V2 scaffold ZM109 HIV-1 strain

immunoglobulin, immune recognition, immune system, glycan, HIV-1, V1V2, Envelope glycoprotein