Structural Insights into the Anti- Methicillin-Resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole

(2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyrrolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
BAL 9141, bound form; ceftobiprole, bound form

Structural Insights into the Anti-methicillin-resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole.

20 mg/mL protein, 5 mM NaHCO3, pH 8.0, 150 mM NaCl, soaked in 0.1mM inhibitor in 100 mM Hepes, pH 7.0, 1 M NaCl, 28% (v/v) PEG 550 MME and 16 mM CdCl2, VAPOR DIFFUSION, HANGING DROP, temperature 298KK

Penicillin-binding protein 2' (E.C.3.4.16.4)