Crystal structure of mutant ABL kinase domain in complex with small molecule fragment

Proto-oncogene tyrosine-protein kinase ABL1

Abelson murine leukemia viral oncogene homolog 1, c-ABL, p150

1.9M AMMONIUM SULFATE, 150 mM POTASSIUM SODIUM TARTRATE, 100 mM SODIUM CITRATE, pH 5.6, VAPOR DIFFUSION, temperature 292K

DRUG DISCOVERY, ABL KINASE, FRAGMENT BASED, Alternative splicing, ATP-binding, Cell adhesion, Chromosomal rearrangement, Cytoplasm, Cytoskeleton, Kinase, Lipoprotein, Magnesium, Manganese, Metal-binding, Myristate, Nucleotide-binding, Nucleus, Phosphoprotein, Proto-oncogene, SH2 domain, SH3 domain, Transferase