Discovery of MK-8189, a highly potent and selective PDE10A inhibitor for the treatment of schizophrenia

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

18% PEG3350, 0.2M MgCl2, 10mM 2-Mercaptoethanol, 0.1M HEPES, pH7.0

PDE10A, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex