Crystal structure of phosphorylated mimic form of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate

A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT.

NAmPRTase, Nampt, Pre-B cell-enhancing factor, Pre-B-cell colony-enhancing factor 1, Visfatin

200mM NaCl, 100mM Tris-HCl, 15% PEG 3350, 20% Glycerol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K

Crystal structure of human NAMPT complexed with ADP analogue

Crystal structure of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate

Crystal structure of human NAMPT complexed with benzamide and phosphoribosyl pyrophosphate

Crystal structure of phosphorylated mimic form of human NAMPT complexed with benzamide and phosphoribosyl pyrophosphate

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Nicotinamide phosphoribosyltransferase (E.C.2.4.2.12)

TRANSFERASE, NMPRTase, NAmPRTase, Visfatin, beryllium fluoride, nicotinamide D-ribonucleotide, pyrophosphate, the mimic form of phosporylated histidine, Alternative splicing, Cytoplasm, Glycosyltransferase, Phosphoprotein, Polymorphism, Pyridine nucleotide biosynthesis