Crystal structure of human Akt2 in complex with GSK690693

Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.

RAC-beta serine/threonine-protein kinase

RAC-PK-beta, Protein kinase Akt-2, Protein kinase B, beta, PKB beta

14% PEG 4K, 10% isopropanol, pH 8.0, vapor diffusion, temperature 298K

RAC-beta serine/threonine-protein kinase (E.C.2.7.11.1)

human, AKT2, inhibitor, ATP-binding, Kinase, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, TRANSFERASE INHIBITOR