Crystal Structure of Plasmodium Falciparum Spermidine Synthase in Complex with METHYLTHIOADENOSIN AND SPERMIDINE after catalysis in crystal

N-(2-AMINO-PROPYL)-1,4-DIAMINOBUTANE; PA(34)

Three-Dimensional Structures of Plasmodium Falciparum Spermidine Synthase with Bound Inhibitors Suggest New Strategies for Drug Design.

RESIDUES 41-321 (ACCORDING TO UNIPROT SEQUENCE Q8II73)

27 % PEG 3350, 0.1 M MES PH 5.5, 0.1 M AMMONIUM SULPHATE

STRUCTURE OF PLASMODIUM FALCIPARUM SPERMIDINE SYNTHASE IN COMPLEX WITH 1H-BENZIMIDAZOLE-2-PENTANAMINE

THE CONSTRUCT USED FOR CRYSTALLIZATION IS MISSES 40 RESIDUES FROM NATIVE SEQUENCE. RESIDUE LYS 41 FROM UNIPROT SEQUENCE IS N-TERMINAL RESIDUE IN THIS STRUCTURE

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

TRANSFERASE, ANINOPROPYL TRANSFERASE, POLYAMINE PATHWAY. ROSSMANN-LIKE FOLD