Structure of bovine endothelial nitric oxide synthase Y477A mutant heme domain in complex with 6-((((3S, 5R)-5-(((6-AMINO-4- METHYLPYRIDIN-2-YL)METHOXY)METHYL)PYRROLIDIN-3-YL)OXY)METHYL)-4- METHYLPYRIDIN-2-AMINE

6-((((3S, 5R)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine

Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.

CONSTITUTIVE NOS, CNOS, EC-NOS, ENDOTHELIAL NOS, ENOS, NOS TYPE III, NOSIII

20-22% PEG3350, 0.1M CACODYLATE PH 6.0, 150-200 MM MG ACETATE, 5 MM TCEP

STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(((3R,4R)-4 -((5-(PYRIDIN-2-YL)PENTYL)OXY)PYRROLIDIN-3-YL) METHYL)PYRIDIN-2-AMINE

STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(((3R,4R)-4 -((5-(4-METHYLPYRIDIN-2-YL)PENTYL)OXY)PYRROLIDIN-3- YL)METHYL)PYRIDIN-2-AMINE

STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(((3R,4R)-4-((5-(6- AMINOPYRIDIN-2-YL)PENTYL)OXY)PYRROLIDIN-3-YL)METHYL)- 4-METHYLPYRIDIN-2-AMINE

STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(5-(((3R,4R)-4-((6- AMINO-4-METHYLPYRIDIN-2-YL)METHYL)PYRROLIDIN-3-YL) OXY)PENTYL)-4-METHYLPYRIDIN-2-AMINE

STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE Y477A MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6 -(((3R,4R)-4-((5-(4-METHYLPYRIDIN-2-YL)PENTYL)OXY) PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE

STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE L111A MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6 -(((3R,4R)-4-((5-(4-METHYLPYRIDIN-2-YL)PENTYL)OXY) PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE

STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE M336V D597N MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6 -(((3R,4R)-4-((5-(PYRIDIN-2-YL)PENTYL)OXY) PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE

STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE M336V D597N MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6 -(((3R,4R)-4-((5-(4-METHYLPYRIDIN-2-YL)PENTYL)OXY) PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE

STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE H341L MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(((3R ,4R)-4-((5-(PYRIDIN-2-YL)PENTYL)OXY)PYRROLIDIN-3- YL)METHYL)PYRIDIN-2-AMINE

STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE H341L MUTANT HEME DOMAIN IN COMPLEX WITH 6-((((3S, 5R)-5 -(((6-AMINO-4-METHYLPYRIDIN-2-YL)METHOXY)METHYL) PYRROLIDIN-3-YL)OXY)METHYL)-4-METHYLPYRIDIN-2-AMINE

STRUCTURE OF HUMAN INOS HEME DOMAIN IN COMPLEX WITH ( R)-6-(3-AMINO-2-(5-(2-(6-AMINO-4- METHYLPYRIDIN- 2-YL)ETHYL)PYRIDIN-3-YL)PROPYL)-4-METHYLPYRIDIN-2- AMINE

RESIDUE 100 IS FOUND AS AN ARG IN STRUCTURE BUT IS A CYS IN DATABASE

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. U VALUES WITH TLS ADDED. RESIDUES 110 TO 120 IN BOTH CHAIN A AND CHAIN B ARE DISORDERED.

NITRIC OXIDE SYNTHASE, ENDOTHELIAL (E.C.1.14.13.39)