Murine Interleukin-12 receptor beta 1 domain 1 in complex with murine Interleukin-12 beta.

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.

PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)

residues [M1-A22] encode the signal peptide which is most likely removed during translation/folding. residues [G336-H343] encode for cloning scar and purification tag.

Residues [M1-C19] encode the signal peptide which is most likely removed during translation/folding. Residues [G259-H266] encode a cloning scar and purification tag. Serendipitous in-drop proteolysis removed the C-terminal half of the protein.

IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40

IL-12 receptor subunit beta-1,IL-12R subunit beta-1,IL-12R-beta-1,IL-12 receptor beta component

(BCS E4) 20% PEG smear medium, 0.1M MgCl2, 0.1 M KCl, 0.1M PIPES pH 7.0

Part of larger complex imaged by single particle cryo EM as well as crystallography.

complex, inflammation, glycoprotein, immunity, CYTOKINE