Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser, Glu82Asn and Lys101Ala

Engineering an improved crystal contact across a solvent-mediated interface of human fibroblast growth factor 1.

HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF-beta

3.3 M sodium formate and 0.4 M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K

Same protein with mutations Glu81Ala, Glu82Asn and Lys101Ala

Same protein with mutations Glu81Ser and Lys101Ala

crystal packing, Acetylation, Angiogenesis, Developmental protein, Differentiation, Growth factor, Heparin-binding, Mitogen, Polymorphism, HORMONE