Crystal structure of KA1-autoinhibited MARK1 kinase

Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain.

This arrangement of chains is most probable based on spatial considerations and experimental evidence, though there is a possibility that the kinase and UBA domains of chain A may be part of the same polymer chain as the KA1 domain of chain B, and vice versa.
Serine/threonine-protein kinase MARK1,Serine/threonine-protein kinase MARK1
kinase and UBA domain (UNP residues 45-381), KA1 domain (UNP residues 681-795)

MAP/microtubule affinity-regulating kinase 1, PAR1 homolog c, Par1c

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

National Institutes of Health/National Cancer Institute (NIH/NCI)

Serine/threonine-protein kinase MARK1 (E.C.2.7.11.1, 2.7.11.26)

Kinase, CAMKL, KA1 domain, autoinhibition, TRANSFERASE

(chain A and ((resid 53 through 54 and (name N or name CA or name C or name O or name CB )) or resid 55 through 70 or (resid 71 through 72 and (name N or name CA or name C or name O or name CB )) or resid 73 through 77 or (resid 78 and (name N or name CA or name C or name O or name CB )) or resid 79 through 120 or (resid 121 and (name N or name CA or name C or name O or name CB )) or resid 122 through 157 or resid 159 through 230 or (resid 231 through 232 and (name N or name CA or name C or name O or name CB )) or resid 233 through 236 or resid 238 through 270 or (resid 271 and (name N or name CA or name C or name O or name CB )) or resid 272 or (resid 273 and (name N or name CA or name C or name O or name CB )) or resid 274 or (resid 275 and (name N or name CA or name C or name O or name CB )) or resid 276 through 288 or (resid 289 and (name N or name CA or name C or name O or name CB )) or resid 290 through 302 or (resid 303 and (name N or name CA or name C or name O or name CB )) or resid 304 through 306 or (resid 307 and (name N or name CA or name C or name O or name CB or name CG or name CD )) or resid 308 or (resid 309 and (name N or name CA or name C or name O or name CB )) or resid 310 through 328 or (resid 329 through 330 and (name N or name CA or name C or name O or name CB )) or resid 331 through 333 or (resid 334 and (name N or name CA or name C or name O or name CB )) or resid 335 through 337 or (resid 338 and (name N or name CA or name C or name O or name CB )) or resid 339 through 341 or (resid 342 and (name N or name CA or name C or name O or name CB )) or resid 343 through 345 or resid 347 through 369 or (resid 371 and (name N or name CA or name C or name O or name CB )) or resid 372 through 373))

(chain B and (resid 53 through 67 or (resid 68 and (name N or name CA or name C or name O or name CB or name CG )) or resid 69 or (resid 70 through 72 and (name N or name CA or name C or name O or name CB )) or resid 73 through 157 or resid 159 through 208 or (resid 209 and (name N or name CA or name C or name O or name CB )) or resid 210 or (resid 211 and (name N or name CA or name C or name O or name CB )) or resid 212 through 213 or (resid 214 and (name N or name CA or name C or name O or name CB )) or resid 215 through 236 or resid 238 through 263 or (resid 264 and (name N or name CA or name C or name O or name CB )) or resid 265 through 266 or (resid 267 and (name N or name CA or name C or name O or name CB )) or (resid 268 and (name N or name CA or name C or name O or name CB or name CG )) or resid 269 through 345 or resid 347 through 369 or resid 371 through 373))

(chain A and (resid 696 through 764 or (resid 765 and (name N or name CA or name C or name O or name CB )) or resid 766 through 772 or resid 774 through 795))

(chain B and (resid 696 through 718 or (resid 719 and (name N or name CA or name C or name O or name CB )) or resid 720 through 722 or (resid 723 and (name N or name CA or name C or name O or name CB )) or resid 724 through 734 or (resid 735 and (name N or name CA or name C or name O or name CB )) or resid 736 through 745 or (resid 746 through 750 and (name N or name CA or name C or name O or name CB )) or resid 751 through 772 or resid 774 through 793 or (resid 794 and (name N or name CA or name C or name O or name CB )) or resid 795))