Structure based design of RIP1 kinase inhibitors

Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships.

Receptor-interacting serine/threonine-protein kinase 1

Cell death protein RIP,Receptor-interacting protein 1,RIP-1,Serine/threonine-protein kinase RIP

0.25 M ammonium iodide, 0.03 M glycyl-glycyl-glycine and polyethylene glycol (PEG) 3350 15-25%

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Receptor-interacting serine/threonine-protein kinase 1 (E.C.2.7.11.1)

HUMAN RIPK1 KINASE, CELL CYCLE, Transferase-Transferase Inhibitor complex