Crystal structure of human tankyrase 2 in complex with 2-(4- methoxyphenyl)-3,4-dihydroquinazolin-4-one

Para-Substituted 2-Phenyl-3,4-Dihydroquinazolin-4-Ones as Potent and Selective Tankyrase Inhibitors.

TANK2, ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIKE 6, ARTD6, POLY [ADP-RIBOSE] POLYMERASE 5B, TNKS-2, TRF1-INTERACTING ANKYRIN-RELATED ADP-RIBOSE POLYMERASE 2, TANKYRASE II, TANKYRASE-LIKE PROTEIN, TANKYRASE-RELATED PROTEIN

0.2 M LISO4, 0.1 M TRIS HCL, 22% PEG3350, PH 8.5, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 277K

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 2-PHENYL-3,4-DIHYDROQUINAZOLIN-4-ONE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 2-(4-HYDROXYPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 2-(4-AMINOPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 2-(4-BROMOPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 4-(4-OXO-1,4-DIHYDROQUINAZOLIN-2-YL)BENZONITRILE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 2-(4-(METHYLSULFANYL)PHENYL)-3,4-DIHYDROQUINAZOLIN-4- ONE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 2-(4-TERT-BUTYLPHENYL)-1,4-DIHYDROQUINAZOLIN-4-ONE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 3-METHYL-N-(4-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL )PHENYL)BUTANAMIDE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 2-(4-ACETYLPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH METHYL 4-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL) BENZOATE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 2-(4-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PHENOXY) ACETIC ACID

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 4-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)BENZENE-1- SULFONAMIDE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH (4-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PHENYL) METHANESULFONAMIDE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH N-(4-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PHENYL) THIOPHENE-2-CARBOXAMIDE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 2-(4-(2-OXO-1,3-OXAZOLIDIN-3-YL)PHENYL)-3,4- DIHYDROQUINAZOLIN-4-ONE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 3-((4-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PHENYL) METHYL)IMIDAZOLIDINE-2,4-DIONE

CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 5-METHYL-5-(4-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL) PHENYL)IMIDAZOLIDINE-2,4-DIONE

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

TRANSFERASE, DIPHTHERIA TOXIN LIKE FOLD, ADP- RIBOSYLATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX