Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk

Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates

13-meric peptide from Tyrosine-protein kinase SYK
UNP residues 317-329, pTyr-323 phosphopeptide

c-Cbl TKB domain, CBL N-terminal, UNP residues 23-351

Signal transduction protein CBL, Proto-oncogene c-CBL, Casitas B-lineage lymphoma proto-oncogene, RING finger protein 55

Cas-Br-M (murine) ecotropic retroviral transforming sequence

0.12M ammonium acetate, 18% PEG 3350, pH 6.5, vapor diffusion, hanging drop, temperature 298K

c-Cbl-TKB domain complexed with its binding motif in Sprouty2

c-Cbl-TKB domain complexed with its binding motif in Sprouty4

c-Cbl-TKB domain complexed with its binding motif in EGF receptor

c-Cbl-TKB domain complexed with its binding motif in c-Met

13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL (E.C.6.3.2.-)

Cbl, TKB, ligase, signal transduction, proto-oncogene, complex, Alternative splicing, ATP-binding, Host-virus interaction, Kinase, Nucleotide-binding, Phosphoprotein, Polymorphism, SH2 domain, Transferase, Tyrosine-protein kinase, Ubl conjugation, Calcium, Cytoplasm, Metal-binding, Ubl conjugation pathway, Zinc, Zinc-finger, LIGASE-SIGNALING PROTEIN COMPLEX