E. coli MsbA in complex with LPS and inhibitor G907

(2E)-3-{6-[(1S)-1-(2-chloro-6-cyclopropylphenyl)ethoxy]-4-cyclopropylquinolin-3-yl}prop-2-enoic acid

3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid

Structural basis for dual-mode inhibition of the ABC transporter MsbA.

Lipid A export ATP-binding/permease protein MsbA

3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-[L-glycero-alpha-D-manno-heptopyranose-(1-5)]3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-6)-2-amino-2-deoxy-beta-D-glucopyranose

Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

200 mM NaCl,
19% PEG 550 MME,
4% PEG 400,
100 mM HEPES, pH7.0

Lipid A export ATP-binding/permease protein MsbA (E.C.3.6.3.-)

ABC transporter, inhibitor, LPS, MsbA, LIPID TRANSPORT