Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 1-(2-amino-4- phenylimidazol-1-yl)-3-(2-fluorophenyl)urea at 2.7A resolution

Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-Acyl-Acp Reductase from Pseudomonas Aeruginosa

SAGITALLY FOCUSING GE(220) AND A MULTILAYER

3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG

3-OXOACYL-ACYL-CARRIER-PROTEIN REDUCTASE, 3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE, BETA-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE, BETA-KETOACYL-ACP REDUCTASE, 3-OXOACYL-ACP REDUCTASE

0.1 M SODIUM CACODYLATE PH 6.5, 0.2 M SODIUM CHLORIDE, 2 M AMMONIUM SULPHATE, 1MM 1-(2-AMINO- 4-PHENYLIMIDAZOL-1-YL)-3-(2-FLUOROPHENYL)UREA, FINAL PROTEIN CONCENTRATION 5 MG/ML

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH 2-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE AT 2.3A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH 2-PHENYL-4-(1,2,4-TRIAZOL-4-YL)QUINAZOLINE AT 2.0A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH 1-(2-CHLOROPHENYL)-3-(1-METHYLBENZIMIDAZOL-2-YL) UREA AT 2.5A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH AN UNKNOWN LIGAND AT 1.6A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH 6-(4-(2-CHLOROANILINO)-1H-QUINAZOLIN-2-YLIDENE) CYCLOHEXA-2, 4-DIEN-1-ONE AT 2.3A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH 4-(2-PHENYLTHIENO(3,2-D)PYRIMIDIN-4-YL) MORPHOLINE AT 1.8A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH 1-METHYL-N-PHENYLINDOLE-3-CARBOXAMIDE AT 2.5A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH 1-(4-METHOXY-1-METHYLINDAZOL-3-YL)-3-(2- METHOXYPHENYL)UREA AT 2.4A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH N-(4-CHLORO-2,5-DIMETHOXYPHENYL)QUINOLINE-8- CARBOXAMIDE AT 2.2A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH 1-(1-ETHYLBENZIMIDAZOL-2-YL)-3-(2-METHOXYPHENYL) UREA AT 1.9A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH 2-(3-(TRIFLUOROMETHYL)ANILINO)PYRIDINE-3- SULFONAMIDE AT 2.5A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH N-(2-METHOXYPHENYL)-3,4-DIHYDRO-2H-QUINOLINE-1 -CARBOXAMIDE AT 2.7A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH N-(2-CHLOROPHENYL)-4-PYRROL-1-YL-1,3,5- TRIAZIN-2-AMINE AT 2.6A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH 2,3-DIHYDROINDOL-1-YL-(2-THIOPHEN-3-YL-1,3 -THIAZOL-4-YL)METHANONE AT 2.8A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH N-(2,3-DIHYDRO-1H-INDEN-5-YL)TETRAZOLO(1,5 -B)PYRIDAZIN-6-AMINE AT 2.6A RESOLUTION

CRYSTAL STRUCTURE OF 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (FABG) FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH 5-(2-(FURAN-2-YLMETHOXY)PHENYL)-2-PHENYLTETRAZOLE AT 2.9A RESOLUTION

34X: THE LIGAND 1-(2-AMINO-4-PHENYLIMIDAZOL-1-YL)-3-(2- FLUOROPHENYL)UREA IS BOUND AT THE INTERFACES BETWEEN PROTEIN CHAINS A AND B, AND BETWEEN PROTEIN CHAINS C AND D.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG (E.C.1.1.1.100)

OXIDOREDUCTASE, ROSSMANN FOLD, FATTY ACID BIOSYNTHESIS