Crystal Structure of MT-SP1 in complex with Fab Inhibitor E2

Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition

Chirality errors at ASP204B, ASN137E, and LEU138F.

Serine protease 14, Matriptase, Suppressor of tumorigenicity protein 14, MT-SP1, Prostamin, Serine protease TADG-15, Tumor-associated differentially-expressed gene 15 protein

16% PEG 5000 MME, 0.21M AmSO4, 0.1M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K

Antibody-Protease Complex, Protein-Protein Complex, Enzyme-Inhibitor Complex, Disease mutation, Glycoprotein, Hydrolase, Membrane, Polymorphism, Serine protease, Signal-anchor, Transmembrane