REFINED STRUCTURE OF THE NICOTINIC ACETYLCHOLINE RECEPTOR AT 4A RESOLUTION.

Structure and Gating Mechanism of the Acetylcholine Receptor Pore

NICOTINIC ACETYLCHOLINE RECEPTOR in postsynaptic membrane

THE SPECIMENS WERE TUBULAR CRYSTALS GROWN IN LOW SALT BUFFER FROM ISOLATED TORPEDO POSTSYNAPTIC MEMBRANES. THEY WERE APPLIED TO THE MICROSCOPE GRIDS AND FROZEN IN THE SAME SOLUTION. THESE CRYSTALS WERE TOO SMALL AND DISTORTED TO YIELD MEANINGFUL ELECTRON DIFFRACTION PATTERNS, SO BOTH THE AMPLITUDE AND THE PHASE TERMS HAD TO BE MEASURED FROM FOURIER TRANSFORMS OF THE IMAGES. THE IMAGES WERE RECORDED USING A DOSE OF 2000 ELECTRONS/NM2 DURING THE PERIOD: JAN-1996 TO OCT-2002. THE DATASETS INVOLVED 4 HELICAL FAMILIES OF TUBES. STRUCTURES WERE SYNTHESISED FROM THE AMPLITUDE AND PHASE TERMS DERIVED FROM EACH FAMILY. THE FINAL DATASET WAS OBTAINED BY AVERAGING THESE 4 STRUCTURES IN REAL SPACE.

ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA CHAIN

ACETYLCHOLINE RECEPTOR PROTEIN, BETA CHAIN

ACETYLCHOLINE RECEPTOR PROTEIN, DELTA CHAIN

ACETYLCHOLINE RECEPTOR PROTEIN, GAMMA CHAIN

NMR STRUCTURE OF AN ACHR-PEPTIDE (TORPEDO CALIFORNICA,ALPHA-SUBUNIT RESIDUES 182-202) IN COMPLEX WITH ALPHA-BUNGAROTOXIN

STRUCTURE OF ACETYLCHOLINE RECEPTOR PORE FROM ELECTRON IMAGES

X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP)

X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH CARBAMYLCHOLINE

NMR STRUCTURE OF AN MIR PEPTIDE ANALOGUE IN COMPLEX WITH AN FV ANTIBODY FRAGMENT

NMR STRUCTURES OF AN MIR PEPTIDE ANALOGUE IN COMPLEX WITH AN ANTIBODY

HELIX
DETERMINATION METHOD: AUTHOR PROVIDED.

SHEET
THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN
ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW,
TWO SHEETS ARE DEFINED.

ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA CHAIN, ACETYLCHOLINE RECEPTOR PROTEIN, BETA CHAIN, ACETYLCHOLINE RECEPTOR PROTEIN, DELTA CHAIN, ACETYLCHOLINE RECEPTOR PROTEIN, GAMMA CHAIN

ION CHANNEL/RECEPTOR, ACETYLCHOLINE RECEPTOR, ION CHANNEL, ION TRANSPORT, POSTSYNAPTIC MEMBRANE, ION CHANNEL-RECEPTOR complex