Leishmania major pteridine reductase 1 in complex with NADP and biopterin

NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE

Structures of Leishmania Major Pteridine Reductase Complexes Reveal the Active Site Features Important for Ligand Binding and to Guide Inhibitor Design

H REGION METHOTREXATE RESISTANCE PROTEIN

15 MG/ML PROTEIN, 0.1M NAAC/HAC BUFFER PH 5.5, 9% MPEG 5000, 0.05M CAAC2, 293K

ONE ACTIVE SITE, TWO MODES OF REDUCTION CORRELATE THE MECHANISM OF LEISHMANIA PTERIDINE REDUCTASE WITH PTERIN METABOLISM AND ANTIFOLATE DRUG RESISTANCE IN TRPANOSOMES

PTERIDINE REDUCTASE 1 FROM LEISHMANIA MAJOR COMPLEXED WITH NADP+ AND DIHYDROBIOPTERIN

INHIBITION OF LEISHMANIA MAJOR PTERIDINE REDUCTASE (PTR1) BY 2,4,6- TRIAMINOQUINAZOLINE; STRUCTURE OF THE NADP TERNARY COMPLEX.

LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND CB3717

LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND TRIMETHOPRIM

LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADPH

LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND TETRAHYDROBIOPTERIN

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

PTERIDINE REDUCTASE, TRYPANOSOMATIDS, DRUG RESISTANCE, PTERIN, SALVAGE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE, METHOTREXATE RESISTANCE, NADP, OXIDOREDUCTASE