Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-253 and COVOX-75 Fabs

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

alpha-L-fucose; 6-deoxy-alpha-L-galactopyranose; L-fucose; fucose

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

The antigenic anatomy of SARS-CoV-2 receptor binding domain.

Severe acute respiratory syndrome coronavirus 2

Medical Research Council (MRC, United Kingdom)

CAMS Innovation Fund for Medical Sciences (CIFMS)

Spike glycoprotein, COVOX-253 heavy chain, COVOX-253 light chain, COVOX-75 heavy chain, COVOX-75 light chain

SARS-CoV-2, antibody, germline, V-gene, receptor-binding-domain, spike, neutralisation, protection, glycosylation, valency, VIRAL PROTEIN/IMMUNE SYSTEM, VIRAL PROTEIN, IMMUNE SYSTEM, VIRAL PROTEIN-IMMUNE SYSTEM complex

(chain "A" and (resid 1 through 142 or resid 149 through 192 or resid 194 through 228))

(chain "G" and (resid 1 through 142 or resid 149 through 192 or resid 194 through 228))

(chain "B" and (resid 1 through 2 or resid 5 through 8 or resid 12 or resid 14 or resid 16 or resid 20 or resid 23 through 27 or resid 31 or resid 33 through 41 or resid 43 through 44 or resid 46 through 49 or resid 52 through 53 or resid 57 or resid 59 or resid 61 through 76 or resid 78 or resid 80 through 84 or resid 86 through 90 or resid 93 or resid 95 or resid 97 through 99 or resid 101 through 125 or resid 127 through 162 or resid 164 through 193 or resid 195 through 213))

(chain "F" and (resid 1 through 2 or resid 5 through 8 or resid 12 or resid 14 or resid 16 or resid 20 or resid 23 through 27 or resid 31 or resid 34 through 42 or resid 44 through 45 or resid 47 through 50 or resid 53 through 54 or resid 58 or resid 60 or resid 62 through 77 or resid 79 or resid 81 through 85 or resid 87 through 91 or resid 94 or resid 96 or resid 98 through 100 or resid 102 through 126 or resid 128 through 163 or resid 165 through 194 or resid 196 through 214))

(chain "I" and (resid 1 through 2 or resid 5 through 8 or resid 12 or resid 14 or resid 16 or resid 20 or resid 23 through 27 or resid 31 or resid 33 through 41 or resid 43 through 44 or resid 46 through 49 or resid 52 through 53 or resid 57 or resid 59 or resid 61 through 76 or resid 78 or resid 80 through 84 or resid 86 through 90 or resid 93 or resid 95 or resid 97 through 99 or resid 101 through 125 or resid 127 through 162 or resid 164 through 193 or resid 195 through 213))

(chain "C" and (resid 337 through 355 or resid 357 through 384 or resid 390 through 516))

(chain "E" and (resid 337 through 355 or resid 357 through 384 or resid 390 through 516))

(chain "D" and (resid 1 through 188 or resid 190 through 210 or resid 212 through 223 or (resid 224 and (name N or name CA or name C or name O or name CB )) or resid 300 through 401))

(chain "H" and (resid 1 through 188 or resid 190 through 210 or resid 212 through 224 or resid 300 through 401))