Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a.

Crystal Structure of the Cdk4/6 Inhibitory Protein P18Ink4C Provides Insights Into Ankyrin-Like Repeat Structure/Function and Tumor-Derived P16Ink4 Mutations

PROTEIN WAS CRYSTALLIZED FROM 35% PEG 4000, 200 MM MGSO4 AND 200 MM TRIS/HCL PH 8.5, SITTING DROP METHOD, AT 4 DEG. C., vapor diffusion - sitting drop, temperature 277K

TUMOR SUPPRESSOR, CDK4/6 INHIBITOR, ANKYRIN MOTIF