Crystal structure of the NM23-H2 transcription factor complex with dinucleotide d(AG)

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1.

X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution.

NDK B, NDP kinase B, nm23-H2, C-myc purine-binding transcription factor PUF

PEG 1500, 50 mM sodium citrate, 20 mM MgCl2, 5 mM DTT, Crystals soaked with 10 mM d(AG), pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

transcription factor, cancer, nm23 gen, hexamer, Activator, Anti-oncogene, ATP-binding, Cell cycle, DNA-binding, Kinase, Magnesium, Metal-binding, Nucleotide metabolism, Nucleotide-binding, Nucleus, Phosphorylation, Transcription regulation, Transferase