Human deltaF508 NBD1 with three solubilizing mutations

Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry.

Cystic fibrosis transmembrane conductance regulator

39% PEG4000, 0.1M LiCl, 50mM Tris, pH 9.0, 3mM ATP, 5mM MgCl2, 2mM TCEP, VAPOR DIFFUSION, HANGING DROP, temperature 280K

Crystal structure of human NBD1 with Phe508

Crystal structure of human deltaF508 NBD1 with two solublizing mutations.