Crystal structure of Acinetobacter baumannii N5, N10- methylenetetrahydrofolate dehydrogenase-cyclohydrolase (FolD) complexed with NADP cofactor and inhibitor LY354899

4-(7-AMINO-9-HYDROXY-1-OXO-3,3A,4,5-TETRAHYDRO-2,5,6,8,9B-PENTAAZA-CYCLOPENTA[A]NAPHTHALEN-2-YL)-PHENYLCARBONYL-GLUTAMIC ACID

NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE

Acinetobacter Baumannii Fold Ligand Complexes; Potent Inhibitors of Folate Metabolism and a Re-Evaluation of the Ly374571 Structure.

N5, N10- METHYLENETETRAHYDROFOLATE DEHYDROGENASE-CYCLOHYDROLASE

0.1 M BIS-TRIS PH 5.5, 20 % PEG 3350, 0.2 M MGCL2 AND 2 % DIOXANE

CRYSTAL STRUCTURE OF ACINETOBACTER BAUMANNII N5, N10- METHYLENETETRAHYDROFOLATE DEHYDROGENASE-CYCLOHYDROLASE (FOLD) COMPLEXED WITH NADP COFACTOR

CRYSTAL STRUCTURE OF ACINETOBACTER BAUMANNII N5, N10- METHYLENETETRAHYDROFOLATE DEHYDROGENASE-CYCLOHYDROLASE (FOLD) COMPLEXED WITH NADP COFACTOR AND AN INHIBITOR

NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NAP): DISORDERED NICOTINAMIDE AND RIBOSE

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. U VALUES WITH TLS ADDED. RESIDUES WITH DISORDERED SIDE CHAINS ARE MODELED WITH AN OCCUPANCY OF 0.

BIFUNCTIONAL PROTEIN FOLD (E.C.1.5.1.5, 3.5.4.9)