Structure of the Gh92 Family Glycosyl Hydrolase Ccman5 in complex with deoxymannojirimycin

A Bacterial Glycosidase Enables Mannose-6-Phosphate Modification and Improved Cellular Uptake of Yeast-Produced Recombinant Human Lysosomal Enzymes.

N-TERMINAL FRAGMENT CORRESPONDING TO CATALYTIC DOMAIN.

0.2 M NA FLUORIDE, 0.1 M BIS TRIS PROPANE PH 7.5 AND 20% PEG 3350

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. U VALUES REFINED INDIVIDUALLY