The mitotic kinesin Eg5 in complex with Mg-ADP and ispinesib

The Structure of the Ternary Eg5-Adp-Ispinesib Complex

KINESIN-LIKE PROTEIN 1, KINESIN-LIKE SPINDLE PROTEIN HKSP, KINESIN-RELATED MOTOR PROTEIN EG5, EG5, THYROID RECEPTOR-INTERACTING PROTEIN 5, TR-INTERACTING PROTEIN 5, TRIP-5

0.1M TRIS, PH 8.5; 0.02M MGCL2; 20%(W/V) POLYETHYLENE GLYCOL 8000; 4DEGC

CRYSTAL STRUCTURE OF THE MITOTIC KINESIN EG5 IN COMPLEXWITH MG-ADP.

CRYSTAL STRUCTURE OF THE MOTOR PROTEIN KSP IN COMPLEX WITHADP AND MONASTROL

HUMAN EG5 MOTOR DOMAIN BOUND TO MG-ADP AND MONASTROL

CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH INHIBITOR 1

CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH INHIBITOR 13

CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH INHIBITOR 19

CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH INHIBITOR 6

CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH INHIBITOR 9H

CRYSTAL STRUCTURE OF THE MITOTIC KINESIN EG5 IN COMPLEXWITH MG-ADP AND N-(3-AMINOPROPYL)-N-((3- BENZYL-5-CHLORO-4-OXO-3,4-DIHYDROPYRROLO[2,1-F][ 1,2,4]TRIAZIN-2-YL)(CYCLOPROPYL)METHYL)-4- METHYLBENZAMIDE

CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH ADP AND THIOPHENE CONTAINING INHIBITOR 33

CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH ADP AND THIOPHENE CONTAINING INHIBITOR 37

INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE

CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((4-CHLOROPHENYL)DIPHENYLMETHYLTHIO) PROPANOIC ACID

CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (S)-ENASTRON

CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (S)-DIMETHYLENASTRON

CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-FLUORASTROL

CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((S)-2-METHYL-1,1-DIPHENYLBUTYLTHIO )PROPANOIC ACID

THE CRYSTALLIZED CONSTRUCT INCLUDES RESIDUES 1 TO 368 OF HUMAN EG5 PRECEDED BY TWO AMINO ACIDS, GP, A REMNANT OF THE CLEAVED AFFINITY TAG.