Protease Sapp1p from Candida parapsilosis in complex with KB32

3-HYDROXY-4-AMINO-5-PHENYLPENTANOIC ACID

Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis .

100-fold molar inhibitor excess, Cpr=20mg/ml; drops: 0.002ml protein + 0.001ml reservoir; reservoir: 0.1M MES pH 6.5, 30% v/v PEG 400, VAPOR DIFFUSION, HANGING DROP, temperature 292K

Ministry of Education (MoE, Czech Republic)

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY

Candidapepsin (E.C.3.4.23.24), Pepstatin

Secreted aspartic protease, virulence factor, candidiasis, peptidomimetic inhibitors, ANTIBIOTIC