CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH IMIDAZOPYRIDINE INHIBITOR ((4-(6-BROMO-3-(BUTYLAMINO)IMIDAZO(1,2-A)PYRIDIN-2-YL)PHENOXY) ACETIC ACID) AND L-METHIONINE-S-SULFOXIMINE PHOSPHATE.

{4-[6-BROMO-3-(BUTYLAMINO)IMIDAZO[1,2-A]PYRIDIN-2-YL]PHENOXY}ACETIC ACID

Synthesis, Biological Evaluation and X-Ray Crystallographic Studies of Imidazo(1,2-A)Pyridine-Based Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors

Structure of Mycobacterium Tuberculosis Glutamine Synthetase in Complex with a Transition-State Mimic Provides Functional Insights.

Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors.

EQUAL VOLUMES OF MOTHER LIQUOR (0.1 M TRIS-HCL, PH 7.5, 0.2 M MAGNESIUM CHLORIDE, 39% (V/V) PEG 400) AND PROTEIN SOLUTION (13 G/L IN 0.1 M TRIS-HCL, PH 7.5, 0.125 M SODIUM CHLORIDE, 0.004 M MAGNESIUM CHLORIDE, 4%(V/V) DMSO, 0.001 M INHIBITOR, 0.004 M MSOP), HANGING-DROP, VAPOR DIFFUSION, TEMPERATURE 294K.

CRYSTALLOGRAPHIC STRUCTURE OF A RELAXED GLUTAMINESYNTHETASE FROM MYCOBACTERIUM TUBERCULOSIS

MULTICOPY CRYSTALLOGRAPHIC STRUCTURE OF A RELAXED GLUTAMINESYNTHETASE FROM MYCOBACTERIUM TUBERCULOSIS

CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH TRI-SUBSTITUTED IMIDAZOLE INHIBITOR (3-(2-TERT-BUTYL-5-(PYRIDIN-4-YL)-1H- IMIDAZOL-4- YL)QUINOLINE) AND L-METHIONINE-S- SULFOXIMINE PHOSPHATE.

CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH A PURINE ANALOGUE INHIBITOR AND L-METHIONINE-S-SULFOXIMINE PHOSPHATE.

CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH A TRANSITION STATE MIMIC

CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH A PURINE ANALOGUE INHIBITOR.

CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH TRI-SUBSTITUTED IMIDAZOLE INHIBITOR (4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2- YL)-1H- IMIDAZOL-5-YL)PYRIDIN-2-AMINE) AND L- METHIONINE-S- SULFOXIMINE PHOSPHATE

PROTEIN EXPRESSED IN FUSION WITH A N-TERMINAL 9 AMINO ACID
PEPTIDE CONTAINING A SIX HISTIDINE PURIFICATION TAG.
E. COLI STRAIN GJ4745 IS ADENYLYLTRANSFERASE DEFICIENT (
GLNE-)

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. 403-415 ARE EXCLUDED FROM THE NCS DUE TO DIFFERENCES AS A RESULT OF CRYSTAL CONTACTS
LIGASE, NUCLEOTIDE-BINDING, SYNTHETASE, TRI-SUBSTITUTED IMIDAZOLE, TAUT STATE, RV2220, MT2278, GLNA1