Crystal structure of dengue 1 virus envelope glycoprotein in complex with the scFv fragment of the broadly neutralizing human antibody EDE1 C10

alpha-L-fucose; 6-deoxy-alpha-L-galactopyranose; L-fucose; fucose

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses.

Structural basis of potent Zika-dengue virus antibody cross-neutralization.

Recognition determinants of broadly neutralizing human antibodies against dengue viruses.

Dengue virus serotype 1 envelope protein ectodomain

Variable domain from the heavy chain of broadly neutralising antibody EDE1 C10
Single chain variable fragment (scFv) from antibody EDE1 C10

Variable domain from the light chain of broadly neutralising antibody EDE1 C10

Envelope protein E,Flavivirin protease NS2B regulatory subunit,Flavivirin protease NS3 catalytic subunit,Genome polyprotein,Matrix protein,Non-structural protein 1,Non-structural protein 2A,Non-structural protein 2B,Non-structural protein 3,Non-structural protein 4A,Non-structural protein 4B,Peptide 2k,Peptide pr,Protein prM,RNA-directed RNA polymerase NS5,Serine protease NS3,Serine protease subunit NS2B,Small envelope protein M

Envelope protein (Chain A) are present as homodimers on virion surface and this protein is a crystallographic dimer here. Chain H (antibody heavy chain fragment) forms a heterodimer with chain L (antibody light chain fragment).

VIRAL PROTEIN, FLAVIVIRUS, CLASS 2 FUSION PROTEIN, DENGUE, Antibody