Structural insights into the mechanism of p53 regulation by MDM2 acidic domain

Biochimica et biophysica acta. Molecular cell research
The MDMX acidic domain competes with the p53 transactivation domain for MDM2 N-terminal domain binding.

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TROSY was employed for all 3D NMR experiment

Bruker Avance III 700 MHz spectrometer equipped with a 5mm triple resonance inverse cryoprobe with a z-axis gradient