Tumor Suppressor p16ink4a: Structural Characterization of Wild-Type and Mutant
Proteins by NMR and Circular Dichroism

The tumor suppressor p16_INK4 with eight N-terminal amino acids deleted
was expressed in E. coli (p16/delta1-8)

Tevlev, A., Byeion, I. L., Selby, T., Ericson, K., Kim, H-J., Kraynov, V., and
Tsai M-D., "Tumor Suppressor p16ink4a: Structural Characterization of Wild-Type and
Mutant Proteins by NMR and Circular Dichroism," Biochemistry 35, 9475-9487
(1996).

Tumor suppressor p16INK4A: structural characterization of wild-type and mutant proteins by NMR and circular dichroism.

CYCLIN-DEPENDENT KINASE 4 INHIBITOR A (P16INK4A)

Solution Nmr Structure Of Tumor Suppressor P16ink4a, 18 Structures

Mechanism Of G1 Cyclin Dependent Kinase Inhibition From The Structure Of The Cdk6-P16ink4a Tumor Suppressor Complex

Solution Nmr Structure Of Tumor Suppressor P16ink4a, 20 Structures

Solution Nmr Structure Of Tumor Suppressor P16ink4a, Restrained Minimized Mean Structure

alternative protein CDKN2A [Homo sapiens]

cyclin D-dependent kinases 4 and 6-binding protein/p16 product [human, brain tumors, Peptide, 156 aa]

multiple tumor suppressor 1/cyclin-dependent kinase 4 inhibitor p16 [Homo sapiens]

cyclin-dependent kinase 4 inhibitor [Homo sapiens]

cyclin-dependent kinase inhibitor 2A isoform p16INK4a [Homo sapiens]

cyclin-dependent kinase inhibitor 2A [Pan troglodytes]

cyclin-dependent kinase inhibitor 2A isoform p16gamma [Homo sapiens]

PREDICTED: cyclin-dependent kinase inhibitor 2A isoform X2 [Pan paniscus]

PREDICTED: cyclin-dependent kinase inhibitor 2A isoform X5 [Homo sapiens]

RecName: Full=Cyclin-dependent kinase inhibitor 2A; AltName: Full=Cyclin-dependent kinase 4 inhibitor A; Short=CDK4I; AltName:

p16 was cloned by RT-PCR from total RNA from Hela cells with primers using
GeneAmp RT-PCR into NdeI and Bam HI sites of pET-21b phagemid (Novagen).