Solution Structure of thanatin-like derivative 5 in complex with E. coli LptA mutant Q62L

Lipopolysaccharide export system protein LptA, Thanatin-like derivative 5

(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid

(2R)-2-amino-3-methyl-3-sulfanyl-butanoic acid

Peptidomimetic antibiotics disrupt the lipopolysaccharide transport bridge of drug-resistant Enterobacteriaceae.

HYP = hydroxyproline; LE1 = penicillamine; DAB = diaminobutyric acid; 4FO = D-DAB

300 uM [U-13C; U-15N] E. coli Lipopolysaccharide export system protein LptA mutant Q62L,
500 uM Thanatin-like derivative 5, 50 mM sodium phosphate, 150 mM sodium chloride, 90% H2O/10% D2O

E. coli Lipopolysaccharide export system protein LptA mutant Q62L

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