Solution structure of thanatin-like derivative 4 in complex with E.coli LptA

Lipopolysaccharide export system protein LptA, Thanatin-like derivative

(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid

(2R)-2-amino-3-methyl-3-sulfanyl-butanoic acid

Peptidomimetic antibiotics disrupt the lipopolysaccharide transport bridge of drug-resistant Enterobacteriaceae.

The sequence doesnt contain the signaling sequence (Residues 1-27 from UNIPROT entry P0ADV1).
The first residue is numbered 28. The expressed construct is 28-159.
Deposited are coordinates for the structured part containing residues 28-145.

VAN = HYP = Hydroxyproline PEN =penicillamine DAB = diaminobutyric acid DDA = D-DAB

300 uM [U-13C; U-15N] Lipopolysaccharide export system protein LptA, 20 mM Sodiumphosphate, 150 mM NaCl, 90% H2O/10% D2O

Lipopolysaccharide export system protein LptA

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