Solution structure of Boskar4; a de novo designed G-CSF agonist

Mapping Local Conformational Landscapes of Proteins in Solution.

A topological refactoring design strategy yields highly stable granulopoietic proteins.

500 uM [U-100% 15N] Boskar4, 150 mM sodium phosphate, 95% H2O/5% D2O

ElGamacy, Riss, Zhu, Truffault, Murray, Coles