Solution structure of MLKL executioner domain in complex with a fragment

Mixed lineage kinase domain-like protein

2-[(~{S})-methoxy-(4-propan-2-ylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid

Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.

430 uM [U-13C; U-15N] MLKL executioner domain, 700 uM Cpd 5, 100% D2O

400 uM [U-13C; U-15N] MLKL executioner domain, 700 uM Cpd 5, 93% H2O/7% D2O