Guanine-rich oligonucleotide with 5'- and 3'-GC ends form G-quadruplex with A(GGGG)A hexad, GCGC- and G-quartets and two symmetric GG and AA base pair

GC ends control topology of DNA G-quadruplexes and their cation-dependent assembly.

<!DOCTYPE html PUBLIC -//W3C//DTD XHTML 1.0 Strict//EN

Agilent Technologies VNMRS 800 MHz NMR spectrometer

Agilent Technologies DD2 600 MHz NMR spectrometer

1 mM 8% 13C, 8% 15N GCnCG, 175 mM sodium chloride, 10 mM sodium phosphate buffer, 90% H2O/10% D2O

1 mM GCnCG, 175 mM sodium chloride, 10 mM sodium phosphate buffer, 90% H2O/10% D2O

1 mM GCnCG, 175 mM sodium chloride, 10 mM sodium phosphate buffer, 100% D2O

Case, Darden, Cheatham, III, Simmerling, Wang, Duke, Luo, ... and Kollman