Solution Structure of CaM/Kv7.2-hAB Complex

Potassium voltage-gated channel subfamily KQT member 2, Calmodulin

Proceedings of the National Academy of Sciences of the United States of America
Structural basis and energy landscape for the Ca2+ gating and calmodulation of the Kv7.2 K+ channel.

Potassium voltage-gated channel subfamily KQT member 2

Neuroblastoma-specific potassium channel subunit alpha KvLQT2

Voltage-gated potassium channel subunit Kv7.2

1 mM [U-100% 13C; U-100% 15N; U-50% 2H] Kv7.2-hAB, 1 mM [U-100% 13C; U-100% 15N; U-50% 2H] Calmodulin,
120 mM potassium chloride, 20 mM MES, 5 mM CaCl2, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O

500 uM [U-100% 13C; U-100% 15N] Kv7.2-hAB, 500 uM Calmodulin, 120 mM potassium chloride,
20 mM MES, 5 mM CaCl2, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O

250 uM [U-100% 15N] Kv7.2-hAB, 250 uM [U-100% 15N] Calmodulin, 120 mM potassium chloride,
20 mM MES, 5 mM CaCl2, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O

Chen, Arendall, Headd, Keedy, Immormino, Kapral, Murray, Richardson JS, Richardson DC
Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax