NMR solution structure of the homodimeric, autoinhibited state of the CARD9 CARD and first coiled-coil

Caspase recruitment domain-containing protein 9

Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.

1 mM [U-13C; U-15N] CARD9_2-142, 1 mM Zinc, 14 mg/mL filamentous Pf1 bacteriophage, 95% H2O/5% D2O
Brunger, Adams, Clore, Gros, Nilges and Read