Backbone and Side-chain chemical shift assignments of C. elegans TDP2 Ubiquitin Association domain

C. elegans TDP2 Ubiquitin Association domain

Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage.

UBA domain of Tyrosyl DNA phosphodiesterase 2 protein

TDP2 hydrolyzes 5'-tyrosyl DNA adducts formed by abortive topoisomerase II cleavage complexes to allow error-free repair of DNA double-strand breaks

pE-SUMO vector, supplied by LifeSensors Inc., was used to clone-in the codon optimized DNA sequence of C. elegans TDP2 UBA domain (residues 41 to 100)

MNMR, University of Minnesota, Twin Cities

This PDB entry contains crystal structure of the C. elegans TDP2 full-length protein, including the N-terminal Ubiquitin Association domain

Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax