EGFR transmembrane - juxtamembrane (TM-JM) segment in bicelles: MD guided NMR refined structure.

EGFR transmembrane - juxtamembrane (TM-JM) segment

Conformational coupling across the plasma membrane in activation of the EGF receptor.

Architecture and membrane interactions of the EGF receptor.

EGFR Transmembrane - Juxtamembrane segment

M9L (M626 in native sequence)
M27I (M644 in native sequence)

The monomer starts from 1-60 (Chain A) and 61-120 (Chain B) which corresponds to residue numbers 618-673 in EGFR
Residues at the C-terminus(KLWS)represent a non-native tag

EGFR transmembrane - juxtamembrane (TM-JM) segment, 1

EGFR transmembrane - juxtamembrane (TM-JM) segment, 2

PREDICTED: epidermal growth factor receptor-like [Pongo abelii]

3D 15N-13C F1 filtered/F3 edited NOESY-HSQC

Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax

Brunger, Adams, Clore, Gros, Nilges and Read