SOLUTION NMR STRUCTURE OF THE N-TERMINAL PAS DOMAIN OF HERG POTASSIUM CHANNEL

The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation.

Potassium voltage-gated channel subfamily H member 2
Residue 1 is from TEV cleavage site. This polypeptide is the N-terminal PAS domain of hERG Potassium channel.

Structure Of The N-Terminal Domain Of The Human-Erg Potassium Channel

Solution Structure Of The Eag Domain Of The Herg (Kv11.1) K+ Channel

Nmr Solution Structure Of The N-Terminal Pas Domain Of Herg

Crystal Structure Of The N-terminal Truncated Pas Domain From The Herg Potassium Channel

Crystal Structure Of Pas Domain From The Human Erg (herg) Potassium Channel

ether-a-go-go-related protein [Homo sapiens]

potassium channel [Canis lupus familiaris]

putative potassium channel subunit [Homo sapiens]

ether-a-go-go-related protein isoform Merg1a [Mus musculus]

potassium channel protein ERG long isoform [Oryctolagus cuniculus]

potassium voltage-gated channel subfamily H member 2 isoform a [Homo sapiens]

potassium voltage-gated channel subfamily H member 2 [Canis lupus familiaris]

potassium voltage-gated channel subfamily H member 2 [Bos taurus]

potassium voltage-gated channel subfamily H member 2 [Cavia porcellus]

potassium voltage-gated channel subfamily H member 2 [Equus caballus]

RecName: Full=Potassium voltage-gated channel subfamily H member 2; AltName: Full=Ether-a-go-go-related gene potassium channel

RecName: Full=Potassium voltage-gated channel subfamily H member 2; AltName: Full=Eag homolog; AltName: Full=Ether-a-go-go-rela

TPA: voltage-gated potassium channel, subfamily H, member 2 [Bos taurus]

hERG_N-terminal PAS Domain Human 9606 Eukaryota Metazoa Homo sapiens
Potassium voltage-gated channel, subfamily H (eag-related), member 2

DGSA-distance geometry simulated annealing, Generalised Born Energy Minimization, GENERALISED BORN ENERGY MINIMIZATION WITH NMR RESTRAINTS
N15 labeled protein, 10mM HEPES, 3mM TCEP, 5mM OCTYL GLUCOSIDE
N15 and C13 labeled protein, 10mM HEPES, 3mM TCEP, 5mM OCTYL GLUCOSIDE
Case, Darden, Cheatham, III, Simmerling, Wang, Duke, Luo, ... and Kollman